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Prophylactic Activity Of Essential Oil Extracted From Allium Sativum Against Cladosporium Sphaerospermum And Phomopsis Azadirachtae Infections

ABSTRACT

The report of pathogenic potentials of Cladosporium sphaerospermum and Phomopsis azadirachtae in humans, majorly among the farmers is now posing threat to the populace, and the need to search for a preventive measure from readily available, cost effective, ecofriendly, and natural sources will be an ultimate success to be attained. This study was carried out to evaluate the prophylactic activity of essential oil extracted from allium sativum against Cladosporium sphaerospermum and Phomopsis azadirachtae infections. Soil samples were randomly collected fromdifferent farm lands and screened for the presence of Cladosporium sphaerospermum and Phomopsis azadirachtae using appropriate microbiological techniques. The pathological profile of organism and prophylactic potential of cream were assessed by topically exposing them to albino wistar rats for period of 15 days. The study revealed significant (P < 0.05) reduction in the pathological profiles (alopecia, scaly, erythema, macules and ulceration) associated with the dematiaceous fungus, and this was effectively increased in every three days intervals, and more pronounced against Cladosporium sphaerospermum. This study has shown that the studied cream protected the rats from Cladosporium sphaerospermum and Phomopsis azadirachtae infection and could be used as an alternative prophylactic measure to dermatological infection caused by the studied organism.

KEYWORDS: Prophylactic- activity, Essential oil, Allium sativum, Cladosporium sphaerospermum, Phomopsis azadirachtae and Dematiaceous fungus