Supersizing The Neutralizing Activities Of Curcuma Longa And Baphia Nitida Extracts Against Newcastle Disease Virus Using Vitamin C

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Supersizing The Neutralizing Activities Of Curcuma Longa And Baphia Nitida Extracts Against Newcastle Disease Virus Using Vitamin C

ABSTRACT

The global cases of Newcastle disease among poutry farming in Nigeria has severely encroached the economic standard of poutry farmers. This study was undertaken in order to assess the activity of Curcuma longa and Baphia nitida leaves extract against Newcastle Disease Virus (NDV). The phytochemical constituent of ethanolic extract of the plant was determined quantitatively using spectrophotometric and gravimetric methods. The activity of the extract and mixtures against NDV was determined using invivo technique in embryonated chicken eggs. The photochemical constituents of the plant extract revealed the presence of alkaloids, tannins, flavonoids, phenolics, terpenoids, saponins and glycosides. There was decreased in egg weights from 63.18g to 44.12 and embryonic weights from 4.75g to 3.86g of the infected eggs after72h and these were significantly (P < 0.05) increased in these eggs protected with the extract of which the mixture of the Curcuma longa and Baphia nitida recorded the highest weight. There was also significant (P< 0.05) reduction in infectivity of NDV as the embryo – egg weight ratio (EE) and neutralization values increased among the protected eggs, and the mixture of the 2 extract showed the most pronounced activity. Therefore Curcuma longa and Baphia nitida leaves extract exhibited protective activity against NDV and the activity was most pronounced for the mixture of Curcuma longa and Baphia nitida when compared to the individual extract.

 

KEYWORDS: Neutralizing-activities, Curcuma longa, Baphia nitida, Newcastle disease virus, and Vitamin C

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