Effect of Ethanol extract of Justicia carnea on Body Weight and HeamatologyAanalysis of CadmiumIinduced Hepatotoxicity in Wista Albino Rats

Abstract

The study explored the therapeutic potential of ethanol leaf extract of Justicia carnea in male Wistar rats subjected to cadmium-induced hepatotoxicity, focusing on changes in body weight and hematological parameters. Twenty-five rats were divided into five groups: a normal control group, a negative control group exposed to cadmium only, a positive control group treated with silymarin, and two treatment groups administered 100 mg/kg and 300 mg/kg of J. carnea extract, respectively.Rats exposed to cadmium without treatment experienced a reduction in body weight gain over time, suggesting systemic toxicity and overall physiological decline. In contrast, those treated with the ethanol extract of J. carnea showed a significant recovery in body weight, with the higher dose group exhibiting the most notable improvement. This indicates that the extract may counteract the weight loss effects of cadmium toxicity and aid in restoring metabolic balance.In addition, cadmium exposure led to marked declines in packed cell volume, hemoglobin concentration, and red blood cell counts, reflecting hematological impairment and potential anemia. Administration of J. carnea extract significantly reversed these effects, with both treatment groups showing improvements, and the higher dose group demonstrating the greatest enhancement in hematological values. These findings suggest a dose-dependent ability of the extract to stimulate blood formation, which supports its traditional use as a blood tonic.Overall, the ethanol extract of Justicia carnea contributed to weight restoration and improved hematological health in cadmium-exposed rats, reinforcing its potential as a natural remedy for heavy metal-induced toxicity and as a supportive agent for blood and liver function.