Published in Volume 3, Issue 1
The rise of antibiotic resistance poses significant clinical and public health challenges, resulting
in treatment failures and increased mortality. Enteric bacterial diseases are a major concern, underscoring the urgent need for novel antibiotics from natural sources to combat resistant
pathogens effectively.. This study investigates the influence of growth factors on Aspergillus
fumigatus antibiotic production efficacy A total of 100 soil samples were randomly and
aseptically from different hospital dumping sites, and screened for the presence of Aspergillus
fumigatus using appropriate mycological techniques. The fungal isolates were grown in a
submerged culture, and screened for the production of antibiotics. Aspergillus fumigatus strain
DTO402 (AFO402), Aspergillus fumigatus strain F7 (AFF7) and Aspergillus fumigatus strain
KMM4631 (AFK4631) were isolated from the soil samples. The fungal isolates exhibited
significant (P<0.05) production of inhibitory substances when the pH, temperature, carbon and
nitrogen sources were 7.0, 25℃, extracted sugar from Phoenix dactylifera (PD) fruits and NOdZ
(prepared mixture of Rhizobium leguminosarum, soybean meal and Arachis hypogoea nodule
meal) respectively. This study demonstrates the potential of Aspergillus fumigatus strains
(AFO402, AFF7, and AFK4631) isolated from hospital dumping sites as sources of novel
antibiotics. Optimized growth conditions (pH 7.0, 25°C, Phoenix dactylifera sugar, and NOdZ
nitrogen source) significantly enhanced antibiotic production, highlighting the promise of these
fungal isolates in combating antibiotic-resistant enteric bacterial pathogens.
Aike, K. M., Iheukwumere, I. H., Iheukwumere, C. M., Unaeze, B. C. (2025). Influence of Growth Factors on Aspergillus fumigatus Antibiotic Production Efficacy. Tropical Journal of Applied Natural Sciences, Volume 3, Issue 1, 11.
Aike, K. M., Iheukwumere, I. H., Iheukwumere, C. M., Unaeze, B. C.. "Influence of Growth Factors on Aspergillus fumigatus Antibiotic Production Efficacy." Tropical Journal of Applied Natural Sciences, vol. Volume 3, Issue 1, 2025, pp. 11.
Aike, K. M., Iheukwumere, I. H., Iheukwumere, C. M., Unaeze, B. C.. "Influence of Growth Factors on Aspergillus fumigatus Antibiotic Production Efficacy." Tropical Journal of Applied Natural Sciences Volume 3, Issue 1 (2025): 11.
@article{influenceofgrowthfactorsonaspergillusfumigatusantibioticproductionefficacy2025,
author = Aike, K. M., Iheukwumere, I. H., Iheukwumere, C. M., Unaeze, B. C.,
title = Influence of Growth Factors on Aspergillus fumigatus Antibiotic Production Efficacy,
journal = Tropical Journal of Applied Natural Sciences,
year = 2025,
volume = Volume 3, Issue 1,
pages = 11
}
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